Three injectable medicines are licensed in Poland - semaglutide, tirzepatide and liraglutide - alongside two oral medicines: naltrexone with bupropion, and orlistat. All require a prescription, although lower-dose orlistat can also be bought over the counter. PTLO recommends medication when diet and exercise have not worked: for patients with a BMI of 30 or above, and from BMI 27 for those who already have an obesity-related disease. Treatment starts at the lowest dose, which is increased every few weeks.
The three injectable medicines are GLP-1 analogues, molecules that mimic the intestinal hormone signalling fullness. They slow stomach emptying, so meals keep patients full for longer, and strengthen the fullness signal in the brain, allowing patients to eat less without feeling hungry. Tirzepatide also stimulates the receptor for a second intestinal hormone, GIP, and produces the greatest weight loss. Semaglutide and tirzepatide are given once a week, liraglutide daily.
| Active substance | Brand name | Administration | Effectiveness in a trial | Monthly cost |
|---|
| semaglutide 2.4 mg | Wegovy: obesity; Ozempic and Rybelsus: type 2 diabetes only | injection once a week | STEP 1: 14.9 versus 2.4 percent after 68 weeks | PLN 550 to 890 |
| tirzepatide up to 15 mg | Mounjaro: obesity and type 2 diabetes | injection once a week | SURMOUNT-1: 20.9 versus 3.1 percent after 72 weeks | PLN 800 to 1,900 |
| liraglutide 3 mg | Saxenda: obesity; Victoza: type 2 diabetes only | daily injection | SCALE: 8.0 versus 2.6 percent after 56 weeks | PLN 500 to 1,250 |
| naltrexone with bupropion | Mysimba: obesity | tablets twice a day | COR-I: 6.1 versus 1.3 percent after 56 weeks | PLN 370 to 600 |
| orlistat | Xenical: obesity; lower dose available without a prescription | tablets with meals | about 2 to 3 kg more weight loss than placebo after a year | PLN 160 to 350 |
Effectiveness is expressed as weight loss on the medicine compared with placebo. NFZ does not reimburse any of these medicines for obesity. We checked pharmacy prices in September 2026. For Wegovy and Mounjaro, the lower figure is for the lowest dose used in the first weeks, and the upper figure for the full dose. For Saxenda, Mysimba and Xenical, we give the range between pharmacies at the full dose: the same pack of Saxenda costs PLN 320 in one pharmacy and PLN 750 in another, and five pens a month are needed at a dose of 3 mg. Cheaper alternatives to liraglutide are already available: Plyzari and Polidia.
Why a doctor does not prescribe Ozempic for weight loss in someone without diabetes
Ozempic, Wegovy and Rybelsus contain the same semaglutide. However, according to the Ozempic summary of product characteristics, the medicine's licensing document, it is licensed only for type 2 diabetes, at doses up to 2 mg, while Wegovy is licensed for obesity at 2.4 mg, the dose studied in people without diabetes in the STEP programme. A doctor prescribing Ozempic for weight loss is prescribing outside its licensed indications: there are no safety data for the medicine in people without diabetes, and when supplies are short it reduces availability for people with diabetes. For this reason, the Ministry of Health placed Ozempic on its list of medicines at risk of shortages. According to its summary of product characteristics, Mounjaro is licensed for both type 2 diabetes and obesity, so this issue does not arise.