GLP-1 medicines most often cause nausea, vomiting, diarrhoea and constipation; according to the summaries of product characteristics this affects at least one patient in ten, above all in the first weeks and after every increase in the dose. In the STEP 1 trial 4.5 percent of participants stopped treatment for that reason. Less often there are gallstones, reported in 1.6 percent of people treated with semaglutide, and acute pancreatitis. Severe abdominal pain radiating to the back calls for the drug to be stopped and for contact with a doctor the same day. This is why we ask about digestive symptoms at every follow-up appointment, and raise the dose only once the previous one is well tolerated.
Pregnancy, chronic conditions and other medicines during obesity treatment
Liraglutide, semaglutide and tirzepatide should not be used during pregnancy. Before a planned pregnancy, semaglutide should be stopped at least 2 months beforehand and tirzepatide at least one month beforehand. Semaglutide and liraglutide should not be used while breastfeeding. A doctor may consider tirzepatide after an individual assessment of benefits and risks; breastfeeding data are limited.
Semaglutide and liraglutide are not recommended in severe kidney or liver impairment or NYHA class IV heart failure. Tirzepatide does not require a dose adjustment for kidney or liver impairment, but caution is needed in severe impairment because experience is limited. A history of pancreatitis requires caution when considering semaglutide or tirzepatide and does not in itself rule out treatment. If a doctor confirms acute pancreatitis during treatment, the medicine being taken when it occurred should not be restarted.
Liraglutide is not recommended for people aged 75 or older. There are limited data on the use of semaglutide and tirzepatide in people aged 85 or older.
Patients taking tirzepatide and the contraceptive pill are advised to add a barrier method as a precaution. It should be used for 4 weeks after starting treatment and after each dose increase. An alternative is to switch to non-oral contraception after consulting a doctor.
For patients taking insulin or a sulfonylurea, the doctor assesses whether the doses need to be reduced, because combining them with a GLP-1 medicine increases the risk of hypoglycaemia. All current medicines are reviewed to avoid duplicating treatment; semaglutide should not be combined with other GLP-1 receptor agonists. Patients with diabetic retinopathy need eye checks. Sudden deterioration in vision during treatment requires urgent assessment by an ophthalmologist.
Planned general anaesthesia. The patient tells the anaesthetist that they take the medicine, because delayed gastric emptying increases the risk of aspiration.
Counterfeit pens and research-grade semaglutide bought online
Poland's Chief Pharmaceutical Inspectorate (GIF) has warned about falsified semaglutide pens from outside the pharmacy network, and in 2025, together with Poland's Chief Sanitary Inspectorate, about semaglutide sold online as a peptide for research purposes, without a prescription and with no control over the dose or the purity. A drug from a pharmacy, dispensed against a prescription, is the only version with a verified composition and dose. We do not use products from unverified sources in treatment. Before further treatment, the doctor assesses the patient's health and the products used so far.