Medicines used to treat obesity in Poland include orlistat, naltrexone with bupropion, liraglutide, semaglutide and tirzepatide. GLP-1 and GIP are gut hormones released after a meal that help regulate blood sugar. GLP-1 also affects appetite and slows stomach emptying. Liraglutide and semaglutide activate the GLP-1 receptor, while tirzepatide activates two receptors: GIP and GLP-1. These medicines help reduce hunger and food intake. Liraglutide is injected under the skin daily, while injectable semaglutide and tirzepatide are given once a week. The doctor increases the dose gradually, depending on the medicine, treatment response and tolerability.
We consider obesity medication for adults with a BMI of 30 or above, or a BMI of 27 to 29.9 with at least one weight-related condition. The doctor considers the results of diet and physical activity so far and the indications for the particular medicine. For Xenical, the threshold for overweight patients with risk factors is a BMI of 28. An unsuccessful diet alone does not replace the eligibility criteria for medication. Saxenda is injected daily, with the dose gradually increased to 3 mg as directed by the doctor. Injectable Wegovy and Mounjaro are given once a week. Tirzepatide starts at 2.5 mg weekly and increases to 5 mg after 4 weeks. Further increases of 2.5 mg are possible if needed after at least 4 weeks on the current dose. Maintenance doses are 5, 10 or 15 mg. The doctor selects the dose based on treatment response and tolerability.
How far body weight falls in the semaglutide, tirzepatide and liraglutide trials
In the STEP 1 trial, patients on semaglutide 2.4 mg lost on average 14.9 percent of their body weight after 68 weeks, against 2.4 percent in the placebo group; one in two patients on the drug lost at least 15 percent. In the SURMOUNT-1 trial, tirzepatide at a dose of 15 mg produced a fall of 20.9 percent after 72 weeks, against 3.1 percent on placebo. Liraglutide at a dose of 3 mg in the SCALE trial produced a fall of 8.4 kg after 56 weeks, against 2.8 kg on placebo. Participants in these trials did not have type 2 diabetes and also received support with diet and physical activity. These are separate trials, not a direct comparison of the medicines.
At a starting weight of 110 kg, 14.9 percent corresponds to about 16 kg and 20.9 percent to about 23 kg. This illustrates trial averages; it does not predict an individual patient's result.
In the head-to-head SURMOUNT-5 trial in adults with obesity without type 2 diabetes, average weight loss after 72 weeks was 20.2 percent with tirzepatide 10 or 15 mg and 13.7 percent with semaglutide 1.7 or 2.4 mg. The maximum tolerated doses were used. The trial did not include semaglutide 7.2 mg. Health conditions, tolerability and treatment cost also guide the choice of medicine.
Weight stabilisation and stopping medication
Weight stabilises at different times for different people. A plateau does not necessarily mean the medicine has stopped working. If the response is insufficient, we review how the medicine is used, tolerability and adherence to the plan before considering a change. Assessment criteria and timing depend on the medicine. For Mysimba, the assessment 16 weeks after starting treatment determines whether it can continue: the medicine must be stopped if weight loss is below 5 percent. For adults taking Saxenda, treatment must be stopped if body weight has not fallen by at least 5 percent after 12 weeks at 3 mg daily.
In the STEP 1 extension, participants regained an average of about two-thirds of their previous weight loss one year after stopping semaglutide and the lifestyle intervention provided in the trial. We decide individually when to end treatment and agree on a follow-up plan. STEP 1 did not establish that gradual dose reduction prevents weight regain.