Medicines discussed here that are authorised for obesity treatment include Wegovy, Mounjaro, Saxenda, Mysimba and Xenical. This is not a complete list of all therapies or formulations. Choice depends on indications, other conditions, current medicines and tolerability.
How do the indications for Wegovy, Ozempic and Rybelsus differ?
Wegovy is indicated for weight management, whereas Ozempic and Rybelsus are indicated for type 2 diabetes, although all contain semaglutide. Saxenda contains liraglutide at doses up to 3 mg; Victoza is a liraglutide product for diabetes. Mounjaro has indications for both type 2 diabetes and weight management. Use outside an authorised indication requires an individual medical decision; this is neither a blanket prohibition nor permission to interchange products freely.
Injectable Wegovy starts at 0.25 mg weekly and is usually increased over 16 weeks to 2.4 mg. The product information also allows 7.2 mg after at least 4 weeks at 2.4 mg, if needed, in adults whose initial BMI was at least 30. EU documentation also includes oral Wegovy; authorisation does not establish availability of a particular formulation in Polish pharmacies.
Tirzepatide starts at 2.5 mg weekly, increasing to 5 mg after 4 weeks. Further 2.5 mg increases are made after at least 4 weeks only if needed; maintenance doses are 5, 10 or 15 mg. Liraglutide starts at 0.6 mg daily and increases in 0.6 mg steps at intervals of at least a week to 3 mg, depending on tolerability. The doctor determines the dose.
What determines the cost of obesity medicines?
Wegovy, Mounjaro, Saxenda, Mysimba and Xenical are paid for in full when used for obesity. Cost depends on the dose, number of packs and pharmacy. Check both starting and maintenance costs, distinguishing a pack price from the cost of 4 weeks or 30 days. Wegovy 7.2 mg needs a separate estimate. Pharmacies provide current prices and availability.
When can an oral medicine be considered?
Mysimba combines naltrexone and bupropion. In COR-I, a daily dose of 32 mg/360 mg with diet and activity produced an average 6.1% loss after 56 weeks versus 1.3% with placebo. Emotional eating alone does not determine suitability. Contraindications include uncontrolled hypertension, seizures, a history of bipolar disorder, anorexia or bulimia, opioid use, acute alcohol or benzodiazepine withdrawal, and other products containing bupropion or naltrexone. The doctor also checks interactions.
Xenical contains orlistat in 120 mg hard capsules. It inhibits lipases and reduces absorption of some dietary fat; average additional weight loss compared with placebo is a few kilograms over a year. Fatty stools and bowel urgency can occur. A contraindication to a GLP-1 medicine does not automatically establish suitability for oral treatment.
Saxenda is stopped if weight loss is below 5% after 12 weeks at 3 mg; Mysimba after 16 weeks from starting, and Xenical after 12 weeks of treatment, if 5% has not been achieved. Mysimba also requires annual review of continued benefit, cardiovascular risk and maintenance of at least 5% weight loss after a year. These are not universal stopping rules for all medicines.