Wegovy, Mounjaro, Saxenda, Mysimba and Xenical have weight-management indications for appropriately assessed patients. Ozempic and Rybelsus contain the same semaglutide as Wegovy, but are authorised for type 2 diabetes. Mounjaro contains a different substance, tirzepatide. The name, indication, formulation and dose matter when choosing treatment; a name heard from friends is not enough to decide.
Which medicines are authorised for obesity, and which only for type 2 diabetes?
| Brand | Substance | Authorised use | Form and dose |
|---|
Wegovy | semaglutide | obesity | weekly injection, maintenance dose 2.4 mg; 7.2 mg for selected adults under the conditions below |
Ozempic | semaglutide | type 2 diabetes; reimbursement follows separate criteria | weekly injection, up to 2 mg |
Rybelsus | semaglutide | type 2 diabetes | daily tablet |
Saxenda | liraglutide | obesity | daily injection, up to 3 mg |
Victoza | liraglutide | type 2 diabetes | daily injection at a lower dose than for obesity |
Mounjaro | tirzepatide | obesity and type 2 diabetes | weekly injection; initially 2.5 mg, adult maintenance doses 5, 10 or 15 mg |
Mysimba | naltrexone with bupropion | obesity | tablets, outside the GLP-1 group |
Xenical | orlistat | obesity | 120 mg hard capsules, outside the GLP-1 group |
For obesity without diabetes, we choose a product with the appropriate indication, such as Wegovy or Mounjaro, if the patient meets the criteria. This does not mean that everyone will receive a prescription. The doctor considers the specific product and the patient's health, not just the substance name.
Wegovy 7.2 mg may be considered in adults with an initial BMI of at least 30 if a higher dose is needed and they have taken 2.4 mg for at least four weeks. European product information also includes Wegovy tablets for adults. Authorisation does not mean that every form and dose is available in Polish pharmacies; availability must be checked for the specific pack.
Effectiveness, administration and costs
The difference versus placebo was 17.8 percentage points for tirzepatide 15 mg in SURMOUNT-1 and 12.5 points for semaglutide 2.4 mg in STEP 1. Comparing two separate studies does not replace a direct comparison of medicines. Liraglutide in SCALE produced an 8.4 kg reduction after 56 weeks versus 2.8 kg with placebo and requires daily injections. Trial results inform discussions but do not promise a particular number of kilograms.
Cost depends on the product, dose, pack size and pharmacy. Check the current price before starting treatment, and consider the budget when choosing subsequent doses. One pack does not always cover a full month. Prices for older Wegovy doses do not establish the cost of 7.2 mg or the oral formulation.
When do we consider oral treatment?
Naltrexone with bupropion affects appetite and food-related reward mechanisms. In COR-I, weight loss after 56 weeks was 6.1 percent versus 1.3 percent with placebo. Mysimba must not be used in conditions including epilepsy, opioid use and uncontrolled hypertension. Orlistat reduces absorption of about one third of meal fat; after a year it produces, on average, 2 to 3 kg more weight loss than placebo and may cause oily stools, particularly after fatty meals. The choice of tablets or capsules depends on indications, contraindications, tolerability, preferences and cost. A history of pancreatitis requires individual assessment rather than automatically replacing every medicine with an oral product.