Obesity increases the load on the joints and may promote inflammation. Fat tissue produces substances involved in inflammation. However, mechanical load and metabolic processes explain only some of the causes of osteoarthritis in the knees, hips and hand joints. Weight loss can reduce pain and improve function, but it does not reverse structural changes that have already developed in a joint.
How much do everyday activities load the knee?
In the 2010 study by Kutzner and colleagues, forces were measured in five people with sensors built into their knee replacements. The table shows mean peak resultant forces as percentages of body weight. In the last column, the force is calculated for a person weighing 100 kg and expressed as the weight of the corresponding mass. This presentation shows force in kilograms, although the physical unit of force is the newton. The results come from a small group of people with implants, so for a healthy knee they are an approximation.
| Activity | Force as a percentage of body weight | Force at 100 kg body mass as equivalent weight |
|---|
Standing on both legs | 107% | Weight of 107 kg |
Walking on level ground | 261% | Weight of 261 kg |
Going up stairs | 316% | Weight of 316 kg |
Going down stairs | 346% | Weight of 346 kg |
Of the activities shown in the table, the greatest force was measured when going down stairs. For a person weighing 100 kg, it corresponded to the weight of 346 kg. Measuring load alone does not show when pain will appear or how many kilograms a person needs to lose before feeling relief.
How do weight loss and exercise affect knee pain?
In 2005, Messier and colleagues assessed walking in 142 people with knee osteoarthritis. Each kilogram of weight lost corresponded, on average, to a fall of about 40.6 N in peak compressive force on the joint, a little more than four times the change in body weight. This is an average relationship in the study group and cannot be used to calculate how much pain will ease for an individual. The result does not contradict the table, because Kutzner measured force relative to body weight, while Messier measured the change in force with a change in weight.
The eighteen-month IDEA trial included 454 people aged at least 55, with a BMI of 27 to 41 and knee osteoarthritis confirmed on X-ray. In the diet and exercise group, participants lost an average of 10.6 kg, or 11.4% of body weight; in the diet-only group 8.9 kg; and in the exercise-only group 1.8 kg. The group combining diet and exercise reported less pain and better function than the other groups. Compressive forces on the knee were lower in the diet groups than in the exercise-only group. The weight-loss target is set individually: a smaller loss may also help, although losing 10% generally helps more than 5%. Exercise is recommended for people with osteoarthritis even when their weight is not falling.
What did the semaglutide trial show in people with knee osteoarthritis?
The STEP 9 trial, published in 2024, included 407 people with obesity and painful moderate knee osteoarthritis; average BMI was 40.3. After 68 weeks of semaglutide 2.4 mg, body weight fell by an average of 13.7%, compared with 3.2% in the placebo group. Pain on the WOMAC scale, which assesses osteoarthritis symptoms, fell by 41.7 points, compared with 27.5 points with placebo. Physical function on the SF-36 quality-of-life questionnaire improved by 12.0 points, compared with 6.5 points. Both groups received nutrition counselling and advice on physical activity, but the trial cannot show how much of the improvement in the placebo group came from that support. Adverse effects led 6.7% of people taking semaglutide and 3.0% of those on placebo to stop treatment. The trial did not show cartilage regrowth. Average results do not guarantee the same effect in every patient and do not automatically apply to other GLP-1 medicines.
How is a weight-loss target set before joint replacement?
Obesity may increase the risk of complications after joint replacement, including infection. An observational study by Spezia and colleagues, published in 2025, assessed 464 operations: 158 in people with a BMI of at least 45 and 306 in people with a BMI of 40 to 44.9. After BMI was reduced below 45, no significant difference in infection risk was found compared with the reference group, but the result was imprecise and does not allow the risk to be regarded as equal. In people with a BMI of at least 45 who did not reduce their BMI before surgery, infection risk was higher. An observational study does not set a BMI threshold that applies in every hospital. In their 2023 guideline, the American rheumatology and hip and knee surgery societies ACR and AAHKS conditionally advise against delaying indicated joint replacement solely to reach a specific BMI. The recommendation concerns people with advanced disease after unsuccessful non-surgical treatment, and the certainty of evidence was rated low. The surgical team agrees the weight-loss target, surgical risk and date of the operation with the patient.
Before anaesthesia or deep sedation, tell the surgical team about the medicine you take, the dose, the date of the last dose and any digestive symptoms. Joint recommendations from several scientific societies in 2024 allow the medicine to be continued in people without increased risk. The dose-escalation period, a high dose and stomach symptoms need further assessment. In that case, the anaesthetist, surgeon and prescribing doctor agree a preparation plan, which may include a liquid diet for at least 24 hours, a stomach ultrasound or a change in the type of anaesthesia. The team also decides when to restart the medicine after any break.