The medicines with an indication for obesity include Wegovy, Mounjaro, Saxenda, Mysimba and Xenical. Ozempic, Rybelsus and Victoza are authorised for type 2 diabetes, although they contain the same active substances as Wegovy and Saxenda. Who may use a medicine and at what dose is set by the summary of product characteristics of the product, not by the active substance alone.
Why does the same substance have two names and two indications?
A manufacturer authorises a medicine for the group of patients, the form and the doses it has studied. Semaglutide as Wegovy is authorised for obesity; this product at a dose of 2.4 mg was tested in STEP 1. The Wegovy summary of product characteristics now also covers a 7.2 mg injection dose for adults with a starting BMI of 30 or above, after at least 4 weeks on 2.4 mg, as well as a tablet form. Authorisation does not mean that every dose and form is available in Polish pharmacies. The same semaglutide as an injection in doses up to 2 mg is Ozempic, and in tablet form Rybelsus, both intended for the treatment of type 2 diabetes. It is similar with liraglutide: 3 mg in Saxenda for obesity, up to 1.8 mg in Victoza for diabetes. Mounjaro, that is tirzepatide, is authorised for both conditions. Since March 2026 semaglutide has had one further indication in the European Union, in steatohepatitis, under a separate trade name; we write about that in the section on the liver. To a patient without diabetes we prescribe a product with an indication for obesity, because the authorised indication sets who may use the medicine and at what dose in line with its summary of product characteristics.
What does a month of treatment cost in a Lublin pharmacy?
According to a review of the reimbursement list from July 2026, none of the five products discussed is reimbursed for obesity, so the patient pays the full pharmacy price. The monthly cost depends on the product, the dose, the pack size and the pharmacy, which is why we do not give a single figure. Injectable treatment starts with lower doses in the first weeks, but not every patient reaches the highest dose, and prices for lower doses cannot be carried over to the 7.2 mg dose or to tablets. With orlistat the dose does not change, so the cost depends mainly on the pack and the pharmacy. The price of the same pack varies between pharmacies, so before having a prescription dispensed the patient can ask about the price in a few of them.
When do we consider oral treatment?
The doctor considers oral treatment, among other situations, when a GLP-1 analogue injection is contraindicated or poorly tolerated; the choice also depends on other conditions, the patient's preferences and cost. One option is Mysimba, a combination of two substances, naltrexone and bupropion, in tablets. Both components act on brain areas involved in regulating appetite and on the reward system, the centres responsible for the pleasure of eating. Eating in response to emotions does not in itself decide the choice of this medicine; the doctor weighs benefits and risks as with any other product. We do not give it in epilepsy or in uncontrolled high blood pressure, because bupropion raises the risk of seizures and can raise blood pressure, nor in people treated with opioids, because naltrexone blocks the action of those drugs and can bring on withdrawal symptoms. Participants in the COR-I trial lost on average 6.1 percent of their body weight after 56 weeks, against 1.3 percent on placebo. Mysimba is stopped if at least 5 percent of the starting body weight has not been lost after 16 weeks. The second option is orlistat, that is Xenical in 120 mg hard capsules. It reduces the absorption of roughly a third of the fat in a meal and over a year produces a weight loss 2 to 3 kg greater than placebo, with oily, loose stools as a side effect, especially after a fat-rich meal. Orlistat is stopped if at least 5 percent of body weight has not been lost after 12 weeks.