Patients ask why they gain weight even though they watch their diet, and for some of them the work schedule is the cause. The body works to a daily rhythm set by light: melatonin rises in the evening and cortisol towards morning, and glucose tolerance is clearly higher in the morning than in the middle of the night. The same meal eaten at night raises blood glucose more than at midday. Shift work forces people to eat at night and sleep during the day, against this rhythm. After such disruption, insulin levels rise, the lipid profile worsens and appetite for high-calorie food increases.
A meta-analysis of 26 studies with 311,334 participants found that shift work is associated with a 25% higher risk of overweight (relative risk, RR 1.25) and a 17% higher risk of obesity (RR 1.17). A second meta-analysis of 28 studies found an odds ratio (OR) for obesity of 1.23 for night work; the association was stronger for abdominal obesity and permanent night work. In a separate analysis, the risk of type 2 diabetes in shift workers was about 10% higher. These are observational studies, so they show that the factors occur together and do not prove that the schedule itself caused obesity in a particular person; part of the difference comes from diet, lower physical activity and smoking.
How does sleep duration affect weight loss?
In a meta-analysis of more than 600,000 adults, short sleep was associated with more frequent obesity (OR 1.55), and each hour less of sleep was associated with a BMI 0.35 points higher. In an intervention study, ten adults with overweight followed the same calorie deficit during two 14-day periods, once with 8.5 and once with 5.5 hours set aside for sleep. With shorter sleep, the share of fat in the weight lost was 55% lower, the loss of fat-free mass, which includes more than muscle, was 60% higher, and participants felt hungrier. In a second study, carried out at home, 80 adults with overweight who slept less than 6.5 hours extended their sleep by an average of 1.2 hours and ate on average about 270 kcal less per day, without dietary advice. Both studies were short and involved selected groups, so they do not guarantee the same effect in every patient.
| Situation in the studies | What this means for treatment | Result |
|---|
Shift work regardless of system: overweight and obesity | We ask about the schedule at the initial consultation and take it into account in the treatment plan | overweight 25% more often, obesity 17% more often |
Permanent night work compared with rotating shifts | For permanent nights we discuss meal and sleep times in particular detail | odds of obesity 43% higher with permanent nights and 14% higher with rotating shifts |
Abdominal obesity in shift workers | We ask for a waist circumference measurement, not only weight | odds of abdominal obesity 35% higher |
Short sleep in adults | We ask about sleep duration separately for working days and days off | odds of obesity 55% higher |
Weight-loss diet with 5.5 instead of 8.5 hours of sleep, 10 people | We make sure meals contain enough protein and include resistance training | 55% less fat in the weight lost |
Sleep extended by 1.2 hours, 80 people | We discuss sleep together with eating, without postponing dietary changes | about 270 kcal less food a day |
Shift work and type 2 diabetes | We plan blood glucose tests around the schedule and confirm an abnormal result | diabetes about 10% more often |
How do we adapt treatment to the work schedule?
We start with sleep and rest times that are as regular as the schedule allows. A nap after a night shift can help, but it does not replace enough sleep. Next, we set meal times. We suggest eating the main meal before going to work and having a light snack containing protein at night, because a meal eaten at night raises blood glucose more and more often leads to extra eating in the early morning. The time of the last coffee and exposure to bright light are agreed individually, depending on shift and sleep times. Darkening the bedroom windows helps.
The timing of medicines can be adapted to a changing schedule. Semaglutide and tirzepatide are injected once a week at any time of day, so the patient chooses one fixed day of the week. Liraglutide is given daily, preferably at a similar time that fits the patient's routine. Orlistat is taken with meals that contain fat, including night-time meals. A missed dose should not be made up with a double injection, and the rules for changing the injection day and what to do after a missed dose depend on the product, so we discuss them when treatment starts.
Shift work can make obesity treatment harder, but its effect differs between patients. We set the goal and pace of treatment based on health, sleep, the work schedule and the first months of therapy, not on the number of years of shift work alone.