Wegovy, Mounjaro, Saxenda, Mysimba and Xenical are licensed for obesity treatment, while Ozempic and Rybelsus are licensed only for type 2 diabetes. A patient who comes to Nasz Gabinet asking about weight-loss injections usually knows one brand name and does not realise that its active substance is also available in another product with a different indication. We therefore explain the brand names at the initial consultation so that the patient knows what we are discussing.
Which brand names contain semaglutide, liraglutide and tirzepatide?
Three substances appear under six brand names:
- Semaglutide is available as Wegovy (obesity treatment), Ozempic (injections up to 2 mg for type 2 diabetes) and Rybelsus (tablets for type 2 diabetes). The maintenance dose of injectable Wegovy is 2.4 mg weekly. In adults with an initial BMI of 30 or above, a doctor may increase it to 7.2 mg if needed after at least 4 weeks at 2.4 mg. Ozempic reimbursement applies to diabetes when the reimbursement criteria are met.
- Liraglutide is Saxenda (3 mg, obesity) and Victoza (a lower dose, diabetes).
- Tirzepatide has one name, Mounjaro, and one product licensed for both conditions.
When a patient asks about Ozempic for weight loss, they are asking about semaglutide. For obesity we prescribe the version licensed for obesity: Wegovy. Wegovy tablets have also been authorised in the European Union. Authorisation does not mean every formulation and dose is available in Polish pharmacies; availability should be checked before having a prescription dispensed.
Daily or weekly injections, and how much weight can be lost?
Saxenda is injected daily, with the dose gradually increased to 3 mg as directed by the doctor. Injectable Wegovy and Mounjaro are given once a week. Tirzepatide starts at 2.5 mg weekly and increases to 5 mg after 4 weeks. Further increases of 2.5 mg are possible if needed after at least 4 weeks on the current dose. Maintenance doses are 5, 10 or 15 mg. The doctor selects the dose based on treatment response and tolerability.
Results depend on the medicine, dose and study population. In SCALE, liraglutide produced 5.6 kg more weight loss than placebo after 56 weeks. In STEP 1, semaglutide 2.4 mg led to 14.9 percent weight loss after 68 weeks, compared with 2.4 percent on placebo. In SURMOUNT-1, tirzepatide 15 mg led to 20.9 percent after 72 weeks, compared with 3.1 percent. These were separate trials in which medication was combined with diet and physical activity, rather than a direct comparison of the medicines.
Pharmacy costs of Wegovy, Mounjaro and Saxenda
The amounts below are estimates. They cover 4 weeks of treatment for Wegovy and Mounjaro and 30 days for Saxenda. The Wegovy price range covers doses up to 2.4 mg only and does not show the cost of using 7.2 mg.
| Product | Substance | Dose | Estimated price |
|---|
Wegovy | semaglutide | 0.25 to 2.4 mg once weekly | about PLN 550 to 890 for 4 weeks |
Mounjaro | tirzepatide | 2.5 to 15 mg once weekly | for 4 weeks, about PLN 800 at 2.5 mg to about PLN 1,900 at 15 mg |
Saxenda | liraglutide | 3 mg daily | about PLN 500 to 1,250 for 30 days |
The price depends on the pharmacy, dose and pack size. Check the current cost and availability of the particular product before having a prescription dispensed.
How do Mysimba and Xenical work and what results do they offer?
Mysimba, the combination of naltrexone and bupropion, suppresses hunger and reduces the pleasure of eating, so it suits people who eat in response to stress; in COR-I, patients lost 6.1 percent after 56 weeks, compared with 1.3 percent on placebo. Epilepsy, opioid use and uncontrolled hypertension rule it out. Xenical contains orlistat in 120 mg hard capsules. It prevents the absorption of about one third of the fat in a meal in the intestine, produces 2 to 3 kg more weight loss than placebo over a year and causes oily stools after fatty foods.
How do we choose an obesity medicine?
The doctor selects a medicine based on health, the planned weight loss, previous treatment response and tolerability, and the patient's budget. The number of kilograms to lose does not determine the choice on its own. A history of pancreatitis calls for caution and an individual assessment of treatment options. We do not prescribe Ozempic or Rybelsus to treat obesity.