Stop-smoking medicines contain one of four substances: cytisine, nicotine, varenicline or bupropion. For each substance, we give example products, doses and how it works. We also give the results of an analysis of 319 studies prepared by Cochrane: the percentage of people who were not smoking after at least six months in groups using the medicine and in groups without it. Cochrane is an independent scientific organisation that gathers and compares the results of studies on a given topic.
Cytisine
Cytisinicline, also known as cytisine, is the active ingredient of Desmoxan, Tabex and Recigar, at 1.5 mg per tablet or capsule. Its structure resembles nicotine; it stimulates nicotinic receptors in the brain more weakly than nicotine and gradually pushes nicotine out of them, which eases withdrawal symptoms. After six months, 13 percent of people treated with cytisine were not smoking, compared with 6 percent without medication.
Most cytisine products are sold without a prescription. The course lasts 25 days and costs about PLN 40 to 78. For the first 3 days, the patient takes one tablet every 2 hours, up to 6 tablets a day, then less and less often, and stops smoking by day 5 at the latest. Cytisine is not taken during pregnancy or breastfeeding or after a recent heart attack or stroke. It is not recommended for people under 18 or over 65, because it has been poorly studied in these age groups.
Nicotine patches
NiQuitin Przezroczysty is a 24-hour patch that releases 7, 14 or 21 mg of nicotine a day, and Nicorette Invisipatch is a 16-hour patch in strengths of 10, 15 or 25 mg. Nicotine is absorbed through the skin and stays in the body at a steady level, lower than after smoking a cigarette, which reduces the need to smoke. After six months, 8 percent of people using a patch were not smoking, compared with 6 percent without medication.
Patches are sold without a prescription. For people who smoke more than 10 cigarettes a day, a course of NiQuitin patches lasts 10 weeks: 21 mg for 6 weeks, 14 mg for 2 weeks and 7 mg for 2 weeks, and the whole course costs about PLN 606 to 930. We also consider a patch for people who cannot take cytisine, and in people with heart disease we choose it with care.
Nicotine gum, spray and lozenges
Nicorette Classic Gum contains 2 or 4 mg of nicotine, Nicorette Spray 1 mg per spray, and NiQuitin MINI lozenges 1.5, 2 or 4 mg. The nicotine is absorbed through the lining of the mouth and works faster than nicotine from a patch, so patients reach for these products when a sudden craving hits, and strongly dependent people can combine them with a patch. All of them are sold without a prescription. After six months, 9 percent of people using these forms of nicotine were not smoking.
Varenicline
Varenicline, at 0.5 or 1 mg per tablet, is the active ingredient of Champix, a prescription medicine. In September 2026, it was not available in the pharmacies we checked. Varenicline partly stimulates the same nicotinic receptors as cytisine and makes it harder for nicotine from cigarettes to stimulate them fully. After six months, 14 percent of people treated with varenicline were not smoking, compared with 6 percent without medication.
Bupropion
Zyban, a prescription medicine, contained 150 mg of bupropion hydrochloride in a prolonged-release tablet, and its marketing authorisation expired in December 2023. Bupropion blocks the reuptake of noradrenaline and dopamine in the brain, which means these substances, which carry signals between nerve cells, act for longer. According to the manufacturer of Zyban, however, it is not known exactly how the medicine helps people stop smoking. After six months, 9 percent of people treated with bupropion were not smoking.