Stop-smoking medicines differ in how well they work, how much they cost and how many times a day you have to remember them. That is why we give the number of daily doses for each medicine. Prices come from online pharmacies in September 2026. None of these medicines is reimbursed by the NFZ, Poland's National Health Fund.
Cytisine, with the dose falling from 6 to 1 or 2 tablets a day
Desmoxan, Tabex and Recigar contain cytisine, recently also called cytisinicline, at 1.5 mg per tablet or capsule. Cytisine stimulates nicotinic receptors in the brain more weakly than nicotine, so it reduces cravings, and a cigarette smoked during treatment has a weaker effect. The number of tablets falls from 6 to 1 or 2 a day. Most products can be bought without a prescription, and one pack costing about PLN 40 to 78 is enough for the whole course. In a study carried out in Poland in 740 adult smokers who, apart from the medicine, received only brief advice, 8.4 percent of people taking cytisine and 2.4 percent of those taking placebo did not smoke for 12 months after treatment.
The manufacturer of Desmoxan gives the intervals between tablets and the maximum number of tablets a day, not clock times.
| Days of treatment | How often | Maximum per day |
|---|
1 to 3 | every 2 hours | 6 |
4 to 12 | every 2.5 hours | 5 |
13 to 16 | every 3 hours | 4 |
17 to 20 | every 5 hours | 3 |
21 to 25 | 1 or 2 tablets a day | 2 |
The level of cytisine in the blood halves after about 4 hours. The intervals between tablets and the maximum number of doses a day depend on the day of treatment and are shown in the table above. The patient takes the first tablet of the day after waking up. For shift workers, the times for taking the tablets move with the time they get up, but the number of tablets in a day must not exceed the number given in the table. The date of the last cigarette must fall no later than day 5 of treatment. A patient who smokes most at work can agree with the doctor to start treatment so that this day falls on a day off.
A nicotine patch applied once a day
NiQuitin Przezroczysty and Nicorette Invisipatch deliver nicotine through the skin evenly for as long as they are worn, without the tar and carbon monoxide from smoke. The NiQuitin patch, in strengths of 21, 14 or 7 mg, is worn for 24 hours. It can be removed before bed, but a patch worn around the clock is better at curbing the urge to smoke in the morning. The Nicorette Invisipatch, in strengths of 25, 15 or 10 mg, is put on after waking up and removed after 16 hours, before going to bed. So the patient puts it on when they get up, not at a fixed time.
Patches are sold without a prescription, and a 10-week course of 24-hour patches costs about PLN 606 to 930. The international EAGLES trial enrolled 8,144 smokers with and without mental disorders. For 12 weeks, participants took varenicline, bupropion or placebo, and one group wore a 21 mg patch with the dose reduced later. The odds that a participant had not smoked in the last 4 weeks of treatment were more than twice as high with the patch as with placebo (odds ratio 2.15).
Gum, spray and lozenges when a craving hits
Nicorette Classic Gum (2 or 4 mg), Nicorette Spray (1 mg per spray) and NiQuitin MINI lozenges (1.5, 2 or 4 mg) deliver nicotine through the lining of the mouth faster than a patch. They are not used at fixed times, so the patient reaches for them whenever they feel like smoking, including at work. People usually chew 8 to 12 pieces of gum a day, no more than 15, for at least 3 months, and then gradually cut down.
All these forms are sold without a prescription. The patient pays PLN 78 to 100 for 105 pieces of 4 mg gum and PLN 62 to 85 for a spray with 150 doses. Cochrane is an independent scientific organisation whose reviews bring together the results of studies on a given topic. In its review, gum increased the number of people not smoking after at least six months by about half, and a patch combined with gum, spray or lozenges worked better than a single form of nicotine.
Varenicline and bupropion, taken twice a day
Varenicline, the active substance in Champix, acts on the same receptors as cytisine. The patient starts taking it 1 to 2 weeks before the quit date. The dose is 0.5 mg once a day for the first 3 days, 0.5 mg twice a day for the next 4 days, and then 1 mg twice a day until the end of the 12-week course. Zyban contains 150 mg of bupropion in a prolonged-release tablet. Bupropion blocks the reuptake of noradrenaline and dopamine. For the first 3 days, one tablet is taken in the morning, and after that a second one in the afternoon as well, at least 8 hours after the first and not just before bed, because insomnia is a very common side effect. Treatment with bupropion lasts at least 7 weeks.
In the EAGLES trial, the odds of not smoking in the last 4 weeks of treatment were about 3.6 times higher with varenicline than with placebo and about 1.7 times higher than with a patch or bupropion, while with bupropion they were similar to those with a patch. These figures are odds ratios, not percentages of people who quit. Champix requires a prescription, but in September 2026 we did not find it in the pharmacies we checked. Zyban was available on prescription, and its marketing authorisation expired in December 2023. That is why at Nasz Gabinet Katowice the doctor in practice chooses between cytisine and nicotine.