Cytisine and nicotine medicines can be bought without a prescription. Both groups of medicines reduce nicotine cravings, but they differ in how they work, how long treatment lasts and how much a day costs. Effectiveness figures come from the 2023 Cochrane review, which covered 319 clinical trials with 157,179 participants. Cochrane is an international network of researchers that gathers the studies on a given topic and assesses their results together. We checked prices in pharmacies in September 2026.
The review assessed effectiveness by whether people were not smoking after at least six months. The differences shown compare treatment with placebo or no medicine.
How does cytisine work?
Cytisine, sold as Desmoxan, Tabex and Recigar, binds to the same brain receptors as nicotine and stimulates them more weakly, so it eases withdrawal symptoms and reduces the pleasure felt after smoking a cigarette. The course lasts 25 days, and the daily number of tablets falls from 6 to 1 or 2. Smoking must stop by day 5 of treatment. With cytisine, the chance of quitting was more than twice as high as without medication, which means about 7 extra non-smokers for every 100 treated. One pack of 100 tablets is enough for the whole course and cost from about PLN 40 to PLN 78, so a day of treatment costs from PLN 1.60 to about PLN 3.10.
How does a nicotine patch work?
A patch, for example NiQuitin Przezroczysty or Nicorette Invisipatch, continuously releases a small dose of nicotine through the skin, so cravings are weaker for as long as the patch is worn. The NiQuitin patch is worn around the clock, while Invisipatch is worn for 16 hours and removed at night. With NiQuitin patches, a person who smokes more than 10 cigarettes a day applies a 21 mg patch for 6 weeks, then a 14 mg patch for 2 weeks and a 7 mg patch for the last 2 weeks. A patch alone increased the chance of quitting by about a third, that is, by about 2 extra non-smokers per 100 treated. NiQuitin patches for the whole course cost from about PLN 606 to PLN 930, which works out at about PLN 8.70 to PLN 13.30 a day.
When are nicotine gum, spray or lozenges used?
Nicorette Classic Gum with 2 or 4 mg nicotine, Nicorette Spray with 1 mg per dose, and NiQuitin MINI lozenges with 1.5 or 4 mg release nicotine in the mouth, from where it quickly enters the bloodstream. Patients use them when a sudden craving occurs. The spray limit is 2 sprays at once, 4 per hour and 64 per day. When used without a patch, the manufacturers allow no more than 15 pieces of Nicorette Classic Gum or 15 NiQuitin MINI 4 mg lozenges per day. For fast-acting nicotine products, the pooled result was about 3 additional non-smokers per 100 people compared with placebo or no medicine. Combining a patch with one of these products produced results similar to cytisine. Daily cost depends on the number of doses used. One spray from a 150-dose pack cost about PLN 0.41–0.57, and one piece of 4 mg gum from a 105-piece pack about PLN 0.74–0.95.
Can you get varenicline or bupropion?
Varenicline in Champix works similarly to cytisine and helped about 8 additional people per 100 treated stop smoking. Bupropion in Zyban is an antidepressant that helped about 3 additional people per 100 treated quit. Both require prescriptions. Zyban left the market after its authorisation expired at the end of 2023, and none of the pharmacies we checked in September 2026 offered Champix. In practice, the doctor in Radom therefore chooses between cytisine and nicotine medicines, considering the patient's conditions and medication. Patients choosing the treatment plan also receive addiction therapy sessions.