A review of 319 studies involving more than 157,000 adults compared the effectiveness and safety of stop-smoking medicines. Serious side effects were rare, occurring on average in 3 percent of participants. It was not shown that serious side effects occurred clearly more often with cytisine, varenicline or nicotine than in people taking placebo or no medicine. The certainty of this result was, however, rated as low. With bupropion, they may affect 1 more person in 100, although this result is not certain either. Milder and more common symptoms usually appear at the start of treatment. Some of them are caused by quitting smoking itself, not by the medicine.
The Cochrane review used abstinence from smoking after at least six months as the measure of effectiveness. The differences shown compare treatment with placebo or no medicine.
What symptoms can cytisine cause?
In Desmoxan, Tabex and Recigar, the active substance is cytisine, now also called cytisinicline. It stimulates nicotinic receptors more weakly than nicotine, so it eases cravings. In this review, 7 more people in 100 quit smoking with cytisine than in groups without medication. Treatment lasts 25 days, and a pack for the whole course cost about PLN 40 to 78 in online pharmacies in September 2026. Most products are available without a prescription.
According to the manufacturer of Desmoxan, nausea, dry mouth, heartburn, abdominal pain, constipation or diarrhoea occur in at least 1 in 10 people. Insomnia, unusual dreams, headaches, irritability, a faster heartbeat and raised blood pressure are equally common. The manufacturer notes that these symptoms occur mainly at the start of treatment, lessen during the course, and may also result from quitting smoking itself. Cytisine must not be used during pregnancy or breastfeeding, after a recent heart attack or stroke, or in people with unstable angina or significant heart rhythm disorders. The doctor checks other contraindications before recommending it.
What should you watch out for with a nicotine patch?
NiQuitin Przezroczysty is worn for 24 hours, and Nicorette Invisipatch for 16 hours, from waking up to going to bed. Nicotine from the patch is absorbed through the skin and reaches a lower blood level than after a cigarette. A patch alone increased the number of people who quit by 2 in 100. According to the manufacturer of NiQuitin patches, combining a patch with gum or lozenges may work better than a patch alone. Patches are available without a prescription. In September 2026, the patient paid about PLN 606 to 930 for 10 weeks of treatment with 24-hour patches.
The most common side effect of patches is a skin reaction where the patch is applied. It is usually mild and goes away quickly after the patch is removed. Each new patch is put on a different place, and a new patch can go on the same spot after a week at the earliest. Severe redness, itching or swelling lasting more than 4 days, or a rash or hives all over the body, are reasons to stop using the patch and talk to a doctor. With NiQuitin patches, nightmares and insomnia, headaches and dizziness, palpitations and nausea are also very common.
Do gum, spray and lozenges irritate the mouth?
They can, especially at the start of treatment. The patient reaches for Nicorette Classic Gum, Nicorette Spray or NiQuitin MINI lozenges when they feel like smoking. The nicotine is absorbed in the mouth. In a summary of studies given by the manufacturer of Nicorette gum, 16.4 percent of participants reported hiccups after nicotine taken by mouth, compared with 2.3 percent in placebo groups. Hiccups were more common in studies of the spray. Throat irritation was reported by 11.8 percent of people compared with 4.4 percent on placebo, and nausea by 10.4 percent compared with 5.8 percent.
According to the manufacturer of the spray, the most common symptoms appear within the first 2 to 3 weeks and then start to ease. These forms of nicotine increased the number of people who quit by 3 in 100. None of them requires a prescription. In online pharmacies in September 2026, a pack of 105 pieces of 4 mg gum cost PLN 78 to 100, and a spray with 150 doses PLN 62 to 85.
What side effects do varenicline and bupropion have?
Varenicline, found in Champix, partly stimulates nicotinic receptors, like cytisine. It increased the number of people who quit by 8 in 100. Its most common side effect is nausea. In studies in which patients took 1 mg twice a day, 28.6 percent of them had it. It usually appeared at the start of treatment, was mild or moderate and rarely led to stopping treatment. Insomnia, unusual dreams and headaches are also very common. Champix requires a prescription, and in September 2026 it was not available in the pharmacies we checked.
Bupropion, the active substance in Zyban, does not contain nicotine. It increased the number of people who quit by 3 in 100, and insomnia is a very common side effect. Rarely, in about 1 person in 1,000, it causes seizures, so it is not used in people who have or have had seizures. The marketing authorisation for Zyban expired in December 2023.