Each of the available medicines has several decades of history behind it, and cytisine is the oldest. Effectiveness data come from a review of 319 studies published in 2023 by Cochrane, an international scientific organisation that pools the results of clinical trials and assesses how reliable they are. We checked prices in September 2026.
In the Cochrane review, the effectiveness of medicines was assessed on the basis of not smoking after at least six months. The differences given come from comparing treatment with placebo or no medicine.
Where does cytisine come from?
Cytisine is an alkaloid from plants of the legume family, obtained mainly from laburnum seeds. During the Second World War, plants containing it were used as a tobacco substitute, and in Central and Eastern Europe it has been sold as a stop-smoking medicine for more than 50 years. Today, Desmoxan, Tabex and Recigar tablets are available in Polish pharmacies. Each tablet contains 1.5 mg of cytisine.
In the brain, cytisine binds to the receptors that nicotine acts on and stimulates them more weakly than nicotine does. As a result, the patient feels the lack of nicotine less, and smoking during treatment gives less pleasure than before. At first, tablets are taken 2 hours apart, which means up to 6 a day, and the interval gets longer at each stage, until from day 21 to day 25 just 1 or 2 tablets a day are enough. Smoking must stop by day 5 of treatment. Among 100 people taking cytisine, about 7 more quit smoking than among 100 people given a placebo. A pack of 100 tablets, enough for the whole course, cost from PLN 40 to PLN 78.
How were nicotine gum and patches developed?
The idea for the gum came from two doctors at Lund University, who noticed that submarine crews coped badly with enforced breaks from smoking. The chemist Ove Fernö of the Swedish pharmaceutical company Leo worked on the gum from 1969, the first description in a scientific journal appeared in 1973, and the gum went on sale in 1978. The patch has a shorter history. In 1984, American researchers applied a solution containing 9 mg of nicotine to the forearm of a single volunteer. After half an hour, nicotine was detected in his saliva, his heart rate rose by 15 beats per minute, and for 2 hours the nicotine level stayed similar to that seen when smoking cigarettes.
Pharmacies currently offer NiQuitin Clear patches, worn around the clock, and Nicorette Invisipatch, removed before sleep. A new patch is applied once daily, and NiQuitin patches are not used for longer than 10 weeks. Patches increased the number of non-smokers by about 2 per 100 people. Nicorette Classic Gum, NiQuitin MINI lozenges and Nicorette Spray are generally used when cravings increase. For fast-acting nicotine formulations, the pooled result was about 3 additional non-smokers per 100 compared with placebo or no medicine. When Nicorette Classic Gum or NiQuitin MINI 4 mg lozenges are used alone, the daily limit is 15 pieces. Spray has three limits: 2 sprays at once, 4 per hour and 64 per day. Ten weeks of NiQuitin patches cost PLN 606–930, a 150-dose spray PLN 62–85, and 105 pieces of 4 mg gum PLN 78–100.
What links varenicline with cytisine, and where did bupropion come from?
Researchers at Pfizer began their search for a new medicine with cytisine. Its derivatives did not live up to expectations, so varenicline, first made in 1997, was built on a different molecular framework. It works in a similar way, however, as it also stimulates the same receptors more weakly than nicotine. Among people treated with varenicline, sold as Champix, about 8 more per 100 quit smoking than without medication. In May 2021, a carcinogenic impurity, N-nitroso-varenicline, was found in varenicline tablets in amounts exceeding the limits set by the European Medicines Agency. Batches of the medicine were recalled, which led to shortages of varenicline. In September 2026, none of the pharmacies we checked had Champix.
Bupropion was developed as an antidepressant. In a study published in 1997, 615 smokers took bupropion at one of three doses or a placebo for 7 weeks. After a year, 23.1 percent of people taking 300 mg a day and 12.4 percent of those taking placebo were not smoking. In the review of studies, bupropion increased the number of non-smokers by about 3 per 100. Varenicline and bupropion require a prescription, and the marketing authorisation for Zyban, a bupropion medicine, expired in Poland in December 2023.