Medication effectiveness is tested in clinical trials comparing a medicine with a placebo, a tablet without an active ingredient, or another medicine. In 2005, British researchers proposed common standards for assessing these studies. Under those standards, success requires at least 6 months of abstinence from the quit date, allowing no more than 5 cigarettes during that period. This rule is solely for counting research outcomes; it is not advice for patients during treatment. Abstinence is confirmed by a test, such as measuring carbon monoxide in exhaled breath. Participants lost to follow-up are counted as smokers.
A Polish trial of cytisine published in 2011 followed these standards. It involved 740 adult smokers. Half of them took cytisine for 25 days and the other half took a placebo, and both groups received only brief advice. In the year after the end of treatment, 8.4 percent of the cytisine group and 2.4 percent of the placebo group stayed off cigarettes continuously. Gastrointestinal complaints were more common among people taking cytisine.
The results of many trials are brought together by Cochrane, an international network of researchers who assess how reliable clinical trials are. Its 2023 review covered 319 trials of stop-smoking medicines. For each medicine, we state how many extra people out of every 100 treated quit smoking compared with placebo or treatment without medication. Cytisine and all nicotine medicines are sold in pharmacies without a prescription.
What is in cytisine tablets?
Desmoxan, Tabex and Recigar contain cytisine, which is now also called cytisinicline. It is a plant alkaloid found in, among other things, laburnum seeds, and its chemical structure is similar to that of nicotine. Cytisine acts on the same receptors in the brain as nicotine, but more weakly. As a result, nicotine cravings ease, and a cigarette smoked during treatment gives less satisfaction.
The course lasts 25 days. For the first 3 days, the patient takes 6 tablets a day, then fewer and fewer, down to 1 or 2 tablets a day in the last days. They smoke their last cigarette no later than day 5 of treatment. In the Cochrane review, cytisine helped 7 more people out of 100 to quit. In September 2026, 100 tablets, enough for the whole course, cost from about PLN 40 to PLN 78. A doctor will not recommend cytisine to a woman who is pregnant or breastfeeding, or to someone who has recently had a heart attack or stroke, or who has unstable angina or clinically significant heart rhythm disorders.
How do NiQuitin and Nicorette Invisipatch patches differ?
Both patches release nicotine through the skin steadily over many hours. NiQuitin Przezroczysty is worn around the clock, and the strongest patch delivers 21 mg of nicotine over 24 hours. Nicorette Invisipatch is worn for 16 hours, from morning to evening, and comes in strengths of 25, 15 or 10 mg per 16 hours. During treatment, the patient moves on to weaker and weaker patches.
A patch keeps nicotine levels fairly steady throughout the day, but after it is applied, the level rises too slowly to control a sudden, strong craving. With a patch alone, there were 2 extra people who managed to quit for every 100 treated. According to September 2026 prices, NiQuitin patches for 10 weeks cost from about PLN 606 to PLN 930 in total.
What helps with a sudden nicotine craving?
When a craving comes on suddenly, nicotine in gum, a mouth spray or lozenges helps. One dose of Nicorette Spray delivers the least nicotine, 1 mg. Nicorette Classic Gum contains 2 or 4 mg, and NiQuitin MINI lozenges 1.5 or 4 mg. Nicotine from these products passes into the blood through the lining of the cheeks and gums, so it starts working sooner than nicotine from a patch. The patient uses them when the urge to smoke comes and does not exceed the daily limit in the leaflet and the treatment plan.
For fast-acting forms of nicotine, the combined result was about 3 extra non-smokers per 100 compared with placebo or no medicine. In the review, a patch combined with gum, spray or lozenges gave a result close to that of cytisine treatment. According to September 2026 prices, a 150-dose spray cost from PLN 62 to PLN 85, less than 105 pieces of 4 mg gum, which cost from PLN 78 to PLN 100.
How effective are varenicline and bupropion?
Varenicline in Champix acts on nicotinic receptors similarly to cytisine, while bupropion in Zyban is an antidepressant. The review found 8 additional quitters per 100 people treated with varenicline and 3 additional quitters with bupropion. Both require prescriptions. Champix was unavailable in the pharmacies we checked in September 2026. Zyban's marketing authorisation expired in December 2023. In practice, doctors in Słupsk therefore choose cytisine or a nicotine medicine.