Partly. Some people who stopped smoking with the help of a medicine go back to cigarettes months or years later, but in studies of nicotine medicines lasting several years, the benefit of treatment persisted after it ended. The effectiveness figures come from a review of 319 studies published in 2023 by Cochrane, an independent scientific organisation whose authors combine the results of many clinical trials into one analysis and assess how reliable they are. The medicine prices below are from September 2026.
In the Cochrane review, the effectiveness of medicines was assessed on the basis of not smoking after at least six months. The differences given come from comparing treatment with placebo or no medicine.
How does cytisine work and what is known about the effectiveness of treatment?
Desmoxan, Tabex and Recigar tablets each contain 1.5 mg of cytisine, a plant alkaloid whose molecule resembles nicotine. Cytisine occupies the sites in the brain that nicotine acts on, but produces a weaker signal there. As a result, nicotine cravings are weaker, and if the patient smokes despite treatment, the cigarette gives them less pleasure than usual. For the first 3 days, the patient takes no more than 6 tablets a day, then fewer and fewer, and finishes the course after 25 days. They stop smoking no later than day 5. In studies, cytisine increased the number of people who managed to quit by about 7 for every 100 treated. One pack of 100 tablets is enough for the whole course. In September 2026, it cost from PLN 40 to PLN 78.
What the situation looks like a year later is shown by a study from a smoking cessation clinic at a cancer centre in Warsaw. The study included 436 consecutive clinic patients who were recommended cytisine with only brief support. A total of 13.8 percent of all those included did not smoke at all for 12 months, and at the last visit this was confirmed by measuring carbon monoxide in exhaled breath. The study had no comparison group, but according to the authors, this result is similar to that of nicotine treatment. Of the 315 people who took the medicine, 49 stopped it because of side effects, mainly stomach complaints and nausea.
Do patients go back to smoking after nicotine treatment?
Some do, but the advantage of treatment remains. In a pooled analysis of 12 placebo-controlled studies, people treated with nicotine were followed for 2 to 8 years. A total of 4792 people took part. Roughly 30 percent of those who were not smoking after a year later went back to smoking, and this happened about as often after nicotine as after placebo. Most of these relapses occurred 1 or 2 years after the first year. The advantage of nicotine treatment therefore fell from about 11 extra non-smokers per 100 after a year to about 7 per 100 after an average of 4.3 years, but it did not disappear.
The NiQuitin Przezroczysty patch releases nicotine through the skin around the clock, and Nicorette Invisipatch for 16 hours, because it is removed before going to bed. One patch is applied a day, and every few weeks the patient moves on to a weaker one. With a patch alone, about 2 more people per 100 treated quit smoking than without medication. A set of NiQuitin patches for 10 weeks costs from PLN 606 to PLN 930.
Nicorette Classic Gum, Nicorette Spray mouth spray and NiQuitin MINI lozenges are used when a sudden urge to smoke comes, because nicotine is absorbed from them through the lining of the mouth faster than from a patch. The daily limit is 15 pieces of gum or 15 lozenges. The spray is used no more than 2 times at once, 4 times an hour and 64 times a day. For fast-acting forms of nicotine, the combined result was about 3 extra non-smokers per 100 compared with placebo or no medicine. Combining one of these forms of nicotine with a patch gave a result close to that of cytisine treatment. A 150-dose spray cost PLN 62 to PLN 85, and 105 pieces of 4 mg gum cost PLN 78 to PLN 100.
Does a longer course reduce the risk of going back to smoking?
Studies of varenicline suggest so. Varenicline, the active substance in Champix, works in a similar way to cytisine and helped about 8 more people per 100 to quit, while bupropion, the antidepressant in Zyban, helped about 3 more. In a study conducted in 7 countries, 1927 smokers took varenicline for 12 weeks. Of those who stopped smoking during that time, 1210 people were randomly assigned to varenicline or placebo for another 12 weeks. From week 13 to week 52, 43.6 percent of the varenicline group and 36.9 percent of the placebo group did not smoke at all.
In 2019, the same organisation pooled 81 studies on preventing relapse to smoking. Taking varenicline for longer reduced the number of relapses. No clear benefit was shown for taking bupropion for longer, and in people who had quit with help, none was shown for longer use of nicotine either, although the certainty of these results was low.
Varenicline and bupropion are available only on prescription. Zyban lost its marketing authorisation in December 2023, and none of the pharmacies we checked had Champix in September 2026. In practice, therefore, the choice in Opole comes down to cytisine and nicotine medicines. At the follow-up appointment, the doctor discusses with the patient a plan for the weeks after the last dose, and if the patient goes back to smoking, the doctor can plan another course of treatment.