Most stop-smoking medicines act on nicotine receptors in the brain, but in two different ways. Cytisine and varenicline occupy these receptors and stimulate them more weakly than nicotine, while nicotine medicines deliver nicotine without smoke. We give the effectiveness of medicines according to the 2023 Cochrane review, which covered 319 studies. Cochrane is a network of researchers who do not test medicines themselves, but find all the studies on a given treatment and summarise their results. The amounts given are medicine prices offered by the pharmacies we checked in September 2026.
In the Cochrane review, the effectiveness of medicines was assessed on the basis of not smoking after at least six months. The differences given come from comparing treatment with placebo or no medicine.
How does cytisine help people stop smoking?
Cytisine is a plant substance with a structure similar to nicotine, found in Desmoxan, Tabex and Recigar. It binds to nicotine receptors more strongly than nicotine, so over time it takes nicotine's place, although it stimulates the receptors more weakly. According to the manufacturer of Desmoxan, this prevents nicotine from fully stimulating the brain's reward system, and by moderately increasing dopamine levels it eases withdrawal symptoms.
The course lasts 25 days. From day 1 to day 3, one tablet is taken every 2 hours, up to 6 tablets a day. On the following days the intervals get longer, and the patient smokes their last cigarette no later than day 5 of treatment. For every 100 people treated with cytisine, about 7 more stopped smoking than without medication. The 25 days require 100 tablets, which is one pack costing PLN 40 to PLN 78.
Do varenicline and bupropion work in a similar way?
Varenicline, the active substance in Champix, works like cytisine. It stimulates nicotine receptors more weakly than nicotine and makes it harder for nicotine from a cigarette to reach them, which, according to the manufacturer, reduces the pleasure of smoking. With varenicline, about 8 more people per 100 treated quit smoking than without medication. Bupropion, the active substance in Zyban, inhibits the reuptake of noradrenaline and dopamine by nerve cells, and the manufacturer notes that it is not known exactly how it helps people quit. With bupropion, about 3 more people per 100 treated quit smoking than without medication.
Both medicines are prescription-only. Zyban has had no marketing authorisation since the end of 2023, and in September 2026 Champix was not available in any pharmacy we checked. In practice, therefore, a patient in Gliwice is recommended cytisine or a nicotine medicine.
What does nicotine from a patch, gum or spray do?
Nicotine medicines deliver nicotine without tobacco smoke and do not make it harder for nicotine from a cigarette to reach the receptors. That is why, from the quit date, the patient does not light a single cigarette. The same Pittsburgh team tested whether nicotine from medicines also enhances other rewards. After a night without cigarettes, smokers received a nicotine patch or nicotine nasal spray and were more willing to work for the chance to watch a film than after a placebo. The authors suggest this may be one of the reasons why nicotine medicines help people quit smoking.
The NiQuitin Przezroczysty patch is worn around the clock. A person who smokes more than 10 cigarettes a day starts with a 21 mg patch for 6 weeks, then applies a 14 mg patch for 2 weeks and a 7 mg patch for 2 weeks. The Nicorette Invisipatch patch is removed before going to bed, after 16 hours. With a patch alone, about 2 more people per 100 treated quit smoking than without medication, and NiQuitin patches for 10 weeks cost from about PLN 606 to PLN 930.
When the urge to smoke comes on suddenly, the patient reaches for a NiQuitin MINI lozenge, Nicorette Spray mouth spray or Nicorette Classic Gum. Usually 8 to 12 pieces of gum or lozenges a day are enough, and no more than 15 can be used. No more than 2 sprays are taken at a time and 4 within an hour, with no more than 64 a day. For fast-acting forms of nicotine, the combined result was about 3 extra non-smokers per 100 compared with placebo or no medicine. Combining one of these forms of nicotine with a patch gave an effect close to that of cytisine treatment. The cheapest 150-dose spray we found cost PLN 62 and the most expensive PLN 85. For 105 pieces of 4 mg gum, you had to pay at least PLN 78, and PLN 100 in more expensive pharmacies.